Molar Pregnancy (Quick and Dirty - Resident Level)
Hydatidiform Mole "Snowstorm" appearance of a complete mole on TVUS I ntroduction : Molar pregnancy, or a hydatidiform mole, is a type of gestational trophoblastic disease (GTD) that originates from abnormally proliferating placental tissue. Complete mole: one or two sperm fertilize an empty ovum → entirely paternal nuclear DNA Partial mole: two or more sperm fertilize a viable ovum → triploid diandrous monogynic nuclear DNA Evaluation : Complete and partial moles tend to present somewhat differently. Partial moles behave more like a typical pregnancy initially, and they are often only diagnosed incidentally from histological evaluation of expulsed tissue following a spontaneous abortion. A partial mole = symptoms mimicking normal pregnancy A complete mole has more distinguishable symptoms: Vaginal bleeding - due to molar tissue separating from decidua Very high levels of beta-hCG (often > 100,000 mIU/mL) → hyperemesis graviderum Pa...